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The peptide sequence, alanine-histidine-lysine bound to copper, was chosen because of how it interacts with growth factor receptors and anti-apoptotic pathways

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In December 2025, Eli Lilly announced positive topline results from TRIUMPH-4 — a 68-week Phase 3 trial in adults with obesity and knee osteoarthritis — in which retatrutide delivered average weight loss of up to 71.2 lbs alongside substantial reductions in osteoarthritis pain